未折叠蛋白反应的发现

Proteins that are secreted from the cell or inserted into the plasma membrane, transit through the endoplasmic reticulum where they are properly folded and assembled and may undergo post-translational modification. Walter tells the story of the exciting discovery made in his lab of the "unfolded protein response", a feedback pathway that ensures that the cell makes enough ER to properly modify all the secreted proteins in the cell.