动物细胞有丝分裂全过程
动物细胞有丝分裂时染色质凝集成染色体、复制的姐妹染色单体在纺锤丝的牵拉下分向两极，从而产生两个染色体数和遗传性相同的子细胞核的一种细胞分裂类型。通常划分为前期、前中期、中期、后期和末期五个阶段。
精神分裂症：我的大脑中是什么？
Sue在20年前被诊断为精神分裂症。绘画是她的治疗剂，但这也是Sue来表达她的大脑中复杂时而又恐惧的秘密的方式。本视频中Sue去找临床医生Sukhi Shergill。他也画画，但是他使用MRI来画出精神分裂症患者大脑的深处。
亲手模拟有丝分裂与减数分裂的过程
Mr. Andersen uses chromosome beads to simulate both mitosis and meiosis. A brief discussion of gamete formation is also included.
通过实验了解有丝分裂 - Richard McIntosh P2
本视频由科普中国和生物医学大讲堂出品
Richard McIntosh (U. Colorado, Boulder) Part 2: Understanding Mitosis through Experimentation
The second lecture describes some key experiments showing the dynamics of a formed mitotic spindle and the ways these may contribute to accurate chromosome motion. Experiments that reveal aspects of the processes by which chromosomes attach to the spindle are presented. Mitotic motors are introduced and discussed in the light of what they probably do and do not accomplish to effect chromosome motion, including acting to improve the accuracy of chromosome segregation. See more at http://www.ibioseminars.org
有丝分裂后期：染色体向纺锤体两极移动 - Richard McIntosh P3
本视频由科普中国和生物医学大讲堂出品
Richard McIntosh (U. Colorado, Boulder) Part 3: Moving Chromosome to the Spindle Poles: Anaphase A
The third lecture presents evidence, largely from McIntosh's lab, that shows how microtubule depolymerization can move chromosomes in vitro and explores the nature of some of the protein complexes that can couple chromosomes to microtubules and take advantage of this reaction. See more at http://www.ibioseminars.org
基因分裂和RNA剪接 - Melissa Moore P1
本视频由科普中国和生物医学大讲堂出品
Melissa Moore (U. Mass/HHMI) Part 1: Split Genes and RNA Splicing
In the first part of her talk, Dr. Moore explains that eukaryotic pre-mRNA contains long stretches of non-protein coding sequences interspersed with protein coding regions. By recognizing specific sequences, cellular machinery splices out the non-coding introns leaving just the protein-coding exons in mRNA. Although at first glance this may seem like a wasteful process, it is splicing that facilitates the evolution of new genes, and alternative splicing that allows a limited number of genes to produce a large number of proteins.
观察活体细胞的有丝分裂过程
Early microscopic images of cells and subcellular organelles were obtained using fixed cells. In this lecture, Dr. Inoue recalls how, in 1947, he built a polarizing light microscope that allowed him to visualize, for the first time, the dynamic mitotic spindle in live cells.
挖掘有丝分裂基因组的宝藏
Molecular motor proteins are fascinating enzymes that power much of the movement performed by living organisms. In the first part of this lecture, I will provide an overview of the motors that move along cytoskeletal tracks (kinesin and dynein which move along microtubules and myosin which moves along actin). The main focus of this lecture is on how motor proteins work. How does a nanoscale protein convert energy from ATP hydrolysis into unidirectional motion and force production? What tools do we have at our disposal to study them? The first part of the lecture will focus on these questions for kinesin (a microtubule-based motor) and myosin (an actin-based motor), since they have been the subject of extensive studies and good models for their mechanisms have emerged. I conclude by discussing the importance of understanding motor proteins for human disease, in particular illustrating a recent biotechnology effort from Cytokinetics, Inc. to develop drugs that activate cardiac myosins to improve cardiac contractility in patients suffering from heart failure. The first part of the lecture is directed to a general audience or a beginning graduate class.
In the second part of this lecture, I will discuss our laboratories current work on the mechanism of movement by dynein, a motor protein about which we still know very little. This is a research story in progress, where some advances have been made. However, much remains to be done in order to understand how this motor works.
The third (last) part of the lecture is on mitosis, the process by which chromosomes are aligned and then segregated during cell division. I will describe our efforts to find new proteins that are important for mitosis through a high throughput RNAi screen. I will discuss how we technically executed the screen and then focus on new proteins that are we discovered that are involved in generating the microtubules that compose the mitotic spindle. I also discuss the medical importance of studying mitosis, including the development of drugs targeted to mitotic motor proteins, which are currently undergoing testing in clinical trials.
上皮内稳态：细胞分裂
我们的整个身体和我们的器官都覆盖着一个保护性的上皮细胞层。这些细胞不断地复制和死亡和细胞之间的平衡和分裂是维持上皮内稳态的关键。太多的细胞死亡会导致上皮细胞屏障的间隙虽然多余的分裂可能导致上皮性肿瘤的形成。Rosenblatt是理解信号调节上皮感兴趣在她说话的1部分，Rosenblatt描述了她实验室的新发现拉伸激活的上皮细胞的拉伸激活的钙离子通道（piezo1）开放，增加细胞内Ca2+水平和刺激的途径，触发细胞分裂。